Target: bind R3AV · silence R3AF. Specialist candidates from each FcGPT base, scored by the fev-mcc-best verifier (analysis over valid candidates).
| base | valid | selected | full-match | agreement | novelty | expression | edit→WT | glyco |
|---|---|---|---|---|---|---|---|---|
| paper_reproduction | 167 | 25 | 0.69 | 0.85 | 0.55 | 0.811 | 6.4 | 0.01 |
| retraining_v1 | 145 | 25 | 0.91 | 0.96 | 0.92 | 0.728 | 6.2 | 0.01 |
| retraining_v2 | 49 | 2 | 0.18 | 0.59 | 0.63 | 0.799 | 5.3 | 0.27 |
| expression | edit | mutations vs WT |
|---|---|---|
| 0.739 | 8 | L27I, T35M, L36F, M37H, I38K, S39D, P42S, T151G |
| 0.634 | 4 | L27I, T35F, L36M, T151G |