Target: bind R2AR · silence R2AH. Specialist candidates from each FcGPT base, scored by the fev-mcc-best verifier (analysis over valid candidates).
| base | valid | selected | full-match | agreement | novelty | expression | edit→WT | glyco |
|---|---|---|---|---|---|---|---|---|
| paper_reproduction | 194 | 25 | 0.93 | 0.97 | 0.72 | 0.810 | 4.1 | 0.01 |
| retraining_v1 | 191 | 25 | 0.77 | 0.88 | 0.82 | 0.765 | 4.3 | 0.01 |
| retraining_v2 | 82 | 25 | 0.98 | 0.99 | 0.50 | 0.777 | 3.4 | 0.04 |
| expression | edit | mutations vs WT |
|---|---|---|
| 0.905 | 2 | P13C, G22V |
| 0.885 | 3 | P2H, L20S, G22V |
| 0.868 | 3 | G22V, L27V, K31P |
| 0.868 | 5 | G22V, L27V, V154K, K155G, G156K, F157G |
| 0.867 | 3 | G22V, L27I, F28V |