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Profile --10----
Target: bind R2AH · silence R2AR. Specialist candidates from each FcGPT base,
scored by the fev-mcc-best verifier (analysis over valid candidates).
Per-base summary
| base | valid | selected | full-match | agreement |
novelty | expression | edit→WT | glyco |
|---|
| paper_reproduction | 200 | 25 | 0.96 | 0.98 | 1.00 | 0.481 | 7.2 | 0.01 |
|---|
| retraining_v1 | 175 | 25 | 0.87 | 0.94 | 1.00 | 0.798 | 6.1 | 0.00 |
|---|
| retraining_v2 | 92 | 22 | 0.86 | 0.93 | 0.88 | 0.817 | 4.2 | 0.64 |
|---|
Model comparison
Mutational heatmap — retraining_v2
Top selected candidates — retraining_v2
| expression | edit | mutations vs WT |
|---|
| 0.901 | 3 | V87W, L99W, N110K |
| 0.878 | 4 | N82K, A84S, V87W, H95Q |
| 0.871 | 4 | N82K, V87W, H95P, N110K |
| 0.841 | 4 | N82K, A84S, R86S, L99W |
| 0.822 | 3 | N82K, A84S, H95R |