Target: bind FcRn6 · silence R1, R2AH, R2AR, R2B, R3AF, R3AV, R3B. Specialist candidates from each FcGPT base, scored by the fev-mcc-best verifier (analysis over valid candidates).
| base | valid | selected | full-match | agreement | novelty | expression | edit→WT | glyco |
|---|---|---|---|---|---|---|---|---|
| paper_reproduction | 200 | 25 | 1.00 | 1.00 | 0.72 | 0.785 | 5.8 | 0.00 |
| retraining_v1 | 200 | 25 | 1.00 | 1.00 | 0.69 | 0.790 | 5.3 | 0.00 |
| retraining_v2 | 100 | 25 | 1.00 | 1.00 | 0.95 | 0.719 | 6.1 | 0.00 |
| expression | edit | mutations vs WT |
|---|---|---|
| 0.831 | 5 | E18R, L19A, G21K, G22R, P23R |
| 0.827 | 4 | L19T, L20A, G21R, P23R |
| 0.819 | 5 | E18S, L19V, L20T, P23R, D50R |
| 0.817 | 6 | E18R, L20S, G21R, P23A, D50A, V51R |
| 0.816 | 5 | E18R, L19V, G21K, G22R, P23R |