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Profile 01000001
Target: bind FcRn6, R3B · silence R1, R2AH, R2AR, R2B, R3AF, R3AV. Specialist candidates from each FcGPT base,
scored by the fev-mcc-best verifier (analysis over valid candidates).
Per-base summary
| base | valid | selected | full-match | agreement |
novelty | expression | edit→WT | glyco |
|---|
| paper_reproduction | 200 | 25 | 0.96 | 0.99 | 0.99 | 0.881 | 7.6 | 0.00 |
|---|
| retraining_v1 | 200 | 25 | 0.98 | 1.00 | 1.00 | 0.670 | 6.4 | 0.00 |
|---|
| retraining_v2 | 100 | 25 | 0.95 | 0.99 | 0.95 | 0.795 | 4.0 | 0.00 |
|---|
Model comparison
Mutational heatmap — retraining_v2
Top selected candidates — retraining_v2
| expression | edit | mutations vs WT |
|---|
| 0.906 | 2 | L27R, D50A |
| 0.897 | 3 | L27G, T35I, D50A |
| 0.897 | 3 | P23T, L27Q, T35V |
| 0.897 | 3 | P23T, L27E, T35V |
| 0.893 | 3 | L27C, T35I, D50A |