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Profile 01001000
Target: bind FcRn6, R2B · silence R1, R2AH, R2AR, R3AF, R3AV, R3B. Specialist candidates from each FcGPT base,
scored by the fev-mcc-best verifier (analysis over valid candidates).
Per-base summary
| base | valid | selected | full-match | agreement |
novelty | expression | edit→WT | glyco |
|---|
| paper_reproduction | 200 | 25 | 0.94 | 0.99 | 1.00 | 0.578 | 6.5 | 0.00 |
|---|
| retraining_v1 | 200 | 25 | 0.97 | 1.00 | 1.00 | 0.719 | 6.3 | 0.00 |
|---|
| retraining_v2 | 100 | 25 | 0.66 | 0.96 | 0.97 | 0.770 | 4.3 | 0.00 |
|---|
Model comparison
Mutational heatmap — retraining_v2
Top selected candidates — retraining_v2
| expression | edit | mutations vs WT |
|---|
| 0.849 | 2 | G21K, G22A |
| 0.840 | 4 | E18G, L19A, G21N, G22A |
| 0.832 | 3 | E18T, G21N, G22A |
| 0.832 | 3 | E18G, G21N, G22S |
| 0.829 | 3 | E18Y, G21N, G22A |