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Profile 01110000
Target: bind FcRn6, R2AH, R2AR · silence R1, R2B, R3AF, R3AV, R3B. Specialist candidates from each FcGPT base,
scored by the fev-mcc-best verifier (analysis over valid candidates).
Per-base summary
| base | valid | selected | full-match | agreement |
novelty | expression | edit→WT | glyco |
|---|
| paper_reproduction | 200 | 25 | 0.78 | 0.97 | 1.00 | 0.800 | 8.3 | 0.00 |
|---|
| retraining_v1 | 200 | 25 | 0.92 | 0.99 | 1.00 | 0.673 | 7.6 | 0.00 |
|---|
| retraining_v2 | 100 | 25 | 0.80 | 0.97 | 1.00 | 0.689 | 6.5 | 0.00 |
|---|
Model comparison
Mutational heatmap — retraining_v2
Top selected candidates — retraining_v2
| expression | edit | mutations vs WT |
|---|
| 0.824 | 4 | L19G, G22A, P114A, Q132E |
| 0.807 | 4 | L19G, G22S, P114A, Q132E |
| 0.790 | 5 | L19S, G21A, G22A, P114R, Q132E |
| 0.788 | 5 | L19G, G21A, G22R, P114A, Q132E |
| 0.773 | 5 | L20G, G21A, G22A, P114A, Q132E |