Target: bind FcRn6, R2AH, R2AR, R3B · silence R1, R2B, R3AF, R3AV. Specialist candidates from each FcGPT base, scored by the fev-mcc-best verifier (analysis over valid candidates).
| base | valid | selected | full-match | agreement | novelty | expression | edit→WT | glyco |
|---|---|---|---|---|---|---|---|---|
| paper_reproduction | 200 | 25 | 0.82 | 0.97 | 1.00 | 0.451 | 7.5 | 0.00 |
| retraining_v1 | 200 | 25 | 0.74 | 0.96 | 1.00 | 0.481 | 7.5 | 0.00 |
| retraining_v2 | 100 | 25 | 0.41 | 0.91 | 1.00 | 0.534 | 6.9 | 0.00 |
| expression | edit | mutations vs WT |
|---|---|---|
| 0.724 | 8 | E18A, L19S, L20I, G21T, L27M, L36F, Q132E, T151G |
| 0.723 | 7 | E18A, L19S, L20V, G21T, L27M, L36F, Q132E |
| 0.696 | 7 | E18A, L19S, L20S, G21I, L27M, L36F, Q132E |
| 0.694 | 8 | E18A, L19F, L20I, G21T, L27M, L36F, Q132E, T151H |
| 0.690 | 7 | E18A, L19S, L20V, G21I, L36F, Q132E, T151G |