← all profiles
Profile 01111111
Target: bind FcRn6, R2AH, R2AR, R2B, R3AF, R3AV, R3B · silence R1. Specialist candidates from each FcGPT base,
scored by the fev-mcc-best verifier (analysis over valid candidates).
Per-base summary
| base | valid | selected | full-match | agreement |
novelty | expression | edit→WT | glyco |
|---|
| paper_reproduction | 200 | 25 | 1.00 | 1.00 | 1.00 | 0.723 | 6.6 | 0.00 |
|---|
| retraining_v1 | 200 | 25 | 0.98 | 1.00 | 1.00 | 0.858 | 5.9 | 0.00 |
|---|
| retraining_v2 | 100 | 25 | 0.95 | 0.99 | 1.00 | 0.623 | 5.3 | 0.00 |
|---|
Model comparison
Mutational heatmap — retraining_v2
Top selected candidates — retraining_v2
| expression | edit | mutations vs WT |
|---|
| 0.870 | 4 | L19S, L20V, Q132E, T151S |
| 0.867 | 3 | L19S, L20V, Q132E |
| 0.846 | 3 | L19F, L20S, Q132E |
| 0.825 | 3 | L20S, L27M, Q132E |
| 0.802 | 4 | E18D, L19P, L20I, Q132E |