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Profile 10111111
Target: bind R1, R2AH, R2AR, R2B, R3AF, R3AV, R3B · silence FcRn6. Specialist candidates from each FcGPT base,
scored by the fev-mcc-best verifier (analysis over valid candidates).
Per-base summary
| base | valid | selected | full-match | agreement |
novelty | expression | edit→WT | glyco |
|---|
| paper_reproduction | 200 | 25 | 0.99 | 1.00 | 0.21 | 0.830 | 4.6 | 0.00 |
|---|
| retraining_v1 | 200 | 25 | 1.00 | 1.00 | 0.96 | 0.821 | 6.4 | 0.00 |
|---|
| retraining_v2 | 100 | 25 | 1.00 | 1.00 | 0.69 | 0.786 | 5.0 | 0.32 |
|---|
Model comparison
Mutational heatmap — retraining_v2
Top selected candidates — retraining_v2
| expression | edit | mutations vs WT |
|---|
| 0.910 | 3 | T35I, M37E, I38G |
| 0.906 | 4 | T35V, L36F, I38R, S39D |
| 0.898 | 4 | T35V, L36F, I38G, T151G |
| 0.898 | 4 | T35I, M37E, I38G, S39D |
| 0.888 | 4 | T35L, L36F, I38G, S39H |