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Profile 11000000
Target: bind R1, FcRn6 · silence R2AH, R2AR, R2B, R3AF, R3AV, R3B. Specialist candidates from each FcGPT base,
scored by the fev-mcc-best verifier (analysis over valid candidates).
Per-base summary
| base | valid | selected | full-match | agreement |
novelty | expression | edit→WT | glyco |
|---|
| paper_reproduction | 200 | 25 | 0.98 | 1.00 | 1.00 | 0.625 | 5.9 | 0.00 |
|---|
| retraining_v1 | 200 | 25 | 0.99 | 1.00 | 1.00 | 0.799 | 4.3 | 0.00 |
|---|
| retraining_v2 | 100 | 25 | 1.00 | 1.00 | 0.88 | 0.772 | 4.1 | 0.00 |
|---|
Model comparison
Mutational heatmap — retraining_v2
Top selected candidates — retraining_v2
| expression | edit | mutations vs WT |
|---|
| 0.889 | 4 | A84L, Y85H, R86T, V87A |
| 0.878 | 5 | N82H, A84V, Y85N, R86T, V87R |
| 0.877 | 5 | N82S, A84L, Y85R, R86T, V87R |
| 0.870 | 3 | N82R, A84V, R86K |
| 0.869 | 4 | N82S, A84V, Y85F, R86K |