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Profile 11000001
Target: bind R1, FcRn6, R3B · silence R2AH, R2AR, R2B, R3AF, R3AV. Specialist candidates from each FcGPT base,
scored by the fev-mcc-best verifier (analysis over valid candidates).
Per-base summary
| base | valid | selected | full-match | agreement |
novelty | expression | edit→WT | glyco |
|---|
| paper_reproduction | 200 | 25 | 0.95 | 0.99 | 1.00 | 0.920 | 7.4 | 0.01 |
|---|
| retraining_v1 | 200 | 25 | 0.95 | 0.99 | 1.00 | 0.440 | 6.7 | 0.00 |
|---|
| retraining_v2 | 100 | 25 | 0.79 | 0.97 | 1.00 | 0.845 | 4.6 | 0.43 |
|---|
Model comparison
Mutational heatmap — retraining_v2
Top selected candidates — retraining_v2
| expression | edit | mutations vs WT |
|---|
| 0.905 | 3 | L27P, N82F, A84T |
| 0.902 | 3 | L27K, N82M, A84T |
| 0.901 | 3 | L27R, N82F, A84T |
| 0.901 | 4 | P23T, T35V, N82W, A84T |
| 0.895 | 3 | L27C, N82P, A84T |