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Profile 11001111
Target: bind R1, FcRn6, R2B, R3AF, R3AV, R3B · silence R2AH, R2AR. Specialist candidates from each FcGPT base,
scored by the fev-mcc-best verifier (analysis over valid candidates).
Per-base summary
| base | valid | selected | full-match | agreement |
novelty | expression | edit→WT | glyco |
|---|
| paper_reproduction | 200 | 25 | 0.78 | 0.97 | 1.00 | 0.585 | 7.3 | 0.00 |
|---|
| retraining_v1 | 200 | 25 | 0.99 | 1.00 | 1.00 | 0.911 | 6.5 | 0.00 |
|---|
| retraining_v2 | 100 | 5 | 0.07 | 0.83 | 0.91 | 0.767 | 3.0 | 0.09 |
|---|
Model comparison
Mutational heatmap — retraining_v2
Top selected candidates — retraining_v2
| expression | edit | mutations vs WT |
|---|
| 0.877 | 2 | L20I, A84Q |
| 0.876 | 2 | E18A, A84E |
| 0.862 | 3 | E18A, L20I, A84R |
| 0.859 | 3 | E18A, L20I, A84N |
| 0.853 | 3 | E18A, L20V, A84E |