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Profile 11110000
Target: bind R1, FcRn6, R2AH, R2AR · silence R2B, R3AF, R3AV, R3B. Specialist candidates from each FcGPT base,
scored by the fev-mcc-best verifier (analysis over valid candidates).
Per-base summary
| base | valid | selected | full-match | agreement |
novelty | expression | edit→WT | glyco |
|---|
| paper_reproduction | 200 | 25 | 0.93 | 0.99 | 1.00 | 0.880 | 7.1 | 0.00 |
|---|
| retraining_v1 | 200 | 25 | 1.00 | 1.00 | 1.00 | 0.890 | 6.2 | 0.01 |
|---|
| retraining_v2 | 100 | 1 | 0.86 | 0.98 | 1.00 | 0.765 | 6.2 | 0.96 |
|---|
Model comparison
Mutational heatmap — retraining_v2
Top selected candidates — retraining_v2
| expression | edit | mutations vs WT |
|---|
| 0.713 | 5 | D55E, Y85D, R86K, P114A, Q132Y |