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Profile 11111001
Target: bind R1, FcRn6, R2AH, R2AR, R2B, R3B · silence R3AF, R3AV. Specialist candidates from each FcGPT base,
scored by the fev-mcc-best verifier (analysis over valid candidates).
Per-base summary
| base | valid | selected | full-match | agreement |
novelty | expression | edit→WT | glyco |
|---|
| paper_reproduction | 200 | 25 | 0.97 | 0.99 | 1.00 | 0.937 | 5.5 | 0.00 |
|---|
| retraining_v1 | 200 | 25 | 0.98 | 1.00 | 1.00 | 0.907 | 6.8 | 0.00 |
|---|
| retraining_v2 | 100 | 25 | 0.66 | 0.94 | 0.98 | 0.521 | 4.7 | 0.01 |
|---|
Model comparison
Mutational heatmap — retraining_v2
Top selected candidates — retraining_v2
| expression | edit | mutations vs WT |
|---|
| 0.904 | 3 | R86K, Q132P, Q147G |
| 0.882 | 4 | R86K, Q132P, Q147G, T151H |
| 0.880 | 3 | D55A, Q132P, Q147L |
| 0.879 | 3 | D55A, Q132P, Q147S |
| 0.878 | 3 | D55A, Q132P, Q147G |