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Profile 11111110
Target: bind R1, FcRn6, R2AH, R2AR, R2B, R3AF, R3AV · silence R3B. Specialist candidates from each FcGPT base,
scored by the fev-mcc-best verifier (analysis over valid candidates).
Per-base summary
| base | valid | selected | full-match | agreement |
novelty | expression | edit→WT | glyco |
|---|
| paper_reproduction | 200 | 25 | 0.99 | 1.00 | 0.99 | 0.665 | 5.9 | 0.00 |
|---|
| retraining_v1 | 200 | 25 | 1.00 | 1.00 | 1.00 | 0.929 | 5.1 | 0.00 |
|---|
| retraining_v2 | 100 | 25 | 0.99 | 1.00 | 0.98 | 0.781 | 4.0 | 0.09 |
|---|
Model comparison
Mutational heatmap — retraining_v2
Top selected candidates — retraining_v2
| expression | edit | mutations vs WT |
|---|
| 0.910 | 3 | E18P, Q132W, Q147D |
| 0.910 | 3 | Q132V, Q147G, T151S |
| 0.909 | 2 | E18S, Q132I |
| 0.902 | 4 | E18S, Q132W, Q147D, T151H |
| 0.890 | 3 | E18P, Q132M, Q147A |